current-1997

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Current-1997

365. Strosberg, A.D., Kota, S., Takahashi, V., Snyder, J.K., Mousseau, G. Core as a Novel Viral Target for Hepatitis C Drugs. Viruses, 2: 1734-51 (2010).

364. Kota, S., Scampavia, L., Spicer, T., Beeler, A.B., Takahashi, V., Snyder, J.K., Porco, J.A. Jr., Hodder, P., Strosberg, A.D. A Time-Resolved Fluorescence-Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization. ASSAY and Drug Development Technologies, 8(1): 96-105, (2010).

363. "New Small Molecule Inhibitors of Hepatitis C Virus." Wei, W, Cai, C, Kota, S, Takahashi, V, Strosberg, AD, Snyder, JK. Bioorganic & Medicinal Chemistry Letters; 19(24): 6926-6930 (2009)

362. Kota, S., Coito, C., Mousseau, G., Lavergne, J-P., and Strosberg, A.D., "Peptide inhibitors of Hepatitis C Virus Core Oligomerization and Virus Production", J. Gen. Virology, 90(Pt 6): 1319-1328, (2009).

361. Strosberg, AD., "Protein-Protein Interactions as Targets for Novel Therapeutics," Touch Briefings Drug Delivery, P 14-15, (2007)
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360. Strosberg, AD., "G-protein-coupled receptor signaling through protein networks," Biochem Soc Trans 35, 1, 23-27, (2007).
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359. Di Benedetto M, Bieche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg, AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. Gene 380, (2), 127-36 (2006).

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358. Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Mol Cell Endocrinol 252,
(1-2), 207-15, (2006).
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357. Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN, Chouchane L. Leptin and leptin receptor polymorphisms are associated
with increased risk and poor prognosis of breast carcinoma. BMC Cancer 6, 38, (2006).
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356. Nouet S., Amzallag N., Li J.M., Louis S., Seitz I., Cui T.X., Alleaume AM., Di Benedetto M., Boden C., Masson M.,Strosberg AD., Horiuchi M.,
Couraud P.O. and Nahmias C. "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein,
ATIP" Journal of Biological Chemistry, 279(28), 28989-28997 (2004).
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355. Strosberg A.D. "Breaking the spell: drug discovery based on modulating protein-protein interactions". Expert Review of Proteomics,
1 (2), 141-143 (2004).
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354. Duport C., Loeper J., Strosberg A.D."Comparative expression of the human beta(2) and beta(3) adrenergic receptors in Saccharomyces cerevisiae." Biochim Biophys Acta. 2003 Oct 1;1629 (1-3), 34-43 (2003).
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353. El-Hadri A, Nicolle E, Leclerc G, Pietri-Rouxel F, Strosberg AD, Archimbault P. "New series of N-substituted phenyl ketone oxime ethers: synthesis and bovine beta3-adrenergic agonistic activities" Pharmazie. 2003 Jan;58 (1), 13-17 (2003).
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352. Friedman-Einat M., Camoin L., Faltin Z., Rosenblum C.I., Kaliouta V., Eshdat Y. & Strosberg AD. "Serum leptin activity in obese and lean patients" Regul Pept. 2003 Mar 28;111 (1-3):77-82 (2003).
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351. Oberkofler, H., Esterbauer, H., Linnemayr, V., Strosberg, A.D., Krempler, F. & Patsch, W. "Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity" J. Biol. Chem. 277, 16750-16757 (2002).
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350. Hazan U., Romero, I.A., Cancello, R., Valente, S., Perrin, V., Mariot, V., Dumonceaux, J., Gerhardt, C.C., Strosberg, A.D., Couraud, P.O. &
Pietri-Rouxel, F. "Human adipose cells express CD4, CXXR4, CCR5 and receptors : a new target cell type for the immunodeficiency virus-1." FASEB J. 16, 1254-1256 (2002).
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349. Strosberg A.D. "Protein Interaction Mapping for Target Validation: the Need for an Integrated Combinatory Process Involving
Complementary Approaches". Cur Op. in Mol. Therapeutics, 4 (6), 594-600 (2002).
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348. Soll D., Strosberg A.D. "Techniques Genome-Wide Technologies: The First Half of the Story". Cur. Op. in Microbiology 5, 311-312 (2002).
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347. Strosberg A.D. "Where is Proteomics Going?" Current Drug Discovery, May 2002
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346. El Hadri, A., Nicolle, E., Guillaume, M.C., Leclerc, G., Pietri-Rouxel, F., Strosberg, A.D., & Archimbault, P., "Synthesis of beta 3-adrenergic agonistic activities of a novel series of aryloxypropamines" Die Pharmazie 56, 517-522 (2001).

345. Legrain P., Strosberg D. "Protein interaction domain mapping for the selection of validated targets and lead compounds in the
anti-infectious area". Current Pharmaceutical Design, 8, 1189-1198 (2001).
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344. Chouchane L., Danguir, J., Beji, C., Bouassida, K., Camoin, L., Sfar, H., Gabbouj, S. & Strosberg, A.D. "Genetic variation in the stress
protein hsp70-2 gene is highly associated with obesity" Int. J. Obes. Relat. Metab. Disord. 25, 462-466 (2001).
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343. Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A.D.,
Patsch, J.R., Krempler, F. & Patsch, W. "A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity
in middle-aged humans" Nat. Genet. 28, 178-183 (2001).
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342. Brydon L., Petit L., Delagrange P., Strosberg, A.D. & Jockers R. "Functional expression of MT2 (Mel1b) melatonin receptors in human
PAZ6 adipocytes" Endocrinology 142, 4264-4271 (2001).
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341. Sugasawa, T., Lenzen, G., Simon, S., Hidaka, J., Cahen, A., Guillaume, J.L., Camoin, L., Nahmias, C. & Strosberg, A.D. "SM-11044 binding
protein (SMBP) belongs to an emerging family of EMP70-related multispanning membrane proteins" Gene 273, 227-237 (2001).
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340. Gerhardt, C.C., Romero, I.A., Cancello, R., Camoin, L. & Strosberg, A.D. "Chemokines control fat accumulation and leptin secretion
by cultured human adipocytes" Mol. & Cell. Endocrinology 175, 81-92 (2001).
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339. Zilberfarb, V., Siquier, K., Strosberg, A.D. & Issad, T. "Effect of dexamethasone on adipocyte differentiation markers and tumour
necrosis factor alpha expression in human PAZ6 cells" Diabetologia 44, 377-386 (2001).
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338. Strosberg A.D. "Functional Proteomics to Exploit Genome Sequences". Cell. Mol. Biology, 47(8), 1295-1299 (2001)
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337. Strosberg, A.D. & Guillaume, J.L. "Expression of beta-adrenergic receptors in recombinant baculovirus-infected insect cells" in
Methods Mol. Biol. 126, 207-214 (2000).
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336. Jockers, R. & Strosberg, A.D. "Expression of beta-adrenergic receptors in E. coli" in Methods Mol. Biol. 126, 215-220 (2000).
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335. Esterbauer, H., Oberkofler, H., Krempler, F., Strosberg, A.D. & Patsch, W. "The uncoupling protein-3 (UCP3) gene is transcribed
from tissue-specific Promoters in humans, but not in rodents" J. Biol. Chem. 275, 36394-36399 (2000).
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334. Anthony, A., Sim, R. Guillaume, J.L., Strosberg, A.D., Dhillon, A.P., Pounder, R.E. & Wakefield, A.J. "Beta 3-adrenergic receptors
in human pancreatic islet and duodenal somastatin neuroendocrine cells" Aliment Pharmacol. Ther. 14, 579-585 (2000).
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333. Hazebrouck, S., Camoin, L., Faltin, Z., Strosberg, .D. & Eshdat, Y. "Enhanced Activity of an Engineered Selenocysteine-Containing
Analog of a Plant Phospholipid Hydroperoxide Glutathione Peroxidase Expressed in E. coli" J. Biol. Chem. 275, 28715-28721 (2000).
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332. Mercer, J., Moar, K.M., Hoggard, N., Strosberg, A.D., Froguel, P. & Bailleul, B. "B219/OB-R 5’UTR and leptin receptor gene-related protein
(OB-RGRP) gene expression in mouse brain and placenta: evidence for tissue-specific leptin receptor promoter activity" J. of
Neuroendocrinology 12, 649-655 (2000).
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331. Elbaz, N., Bedecs, K., Masson, M., Sutren, M., Strosberg, A.D. & Nahmias, C. "Functional transactivation of insulin receptor by growth
inhibitory angiotensin II AT2 receptor" Mol. Endocrinol.14(6) 795-804 (2000).
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330. Texeira, A., Chaverot, N., Strosberg, A.D. & Cazaubon, S. "Differential regulation of cyclin D1 and D3 expression in the control of astrocyte proliferation induced by endothelin-1" J. Neurochem. 74, 1034-1040 (2000).
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329. Proenza, A.M., Poissonnet, C.M., Ozata, M., Ozen, S., Guran, S., Palou, A. & Strosberg, A.D. "Association of sets of alleles of genes encoding beta3-adrenoceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity" Int. J. Obesity 1, 93-100 (2000).
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328. Brydon, L., Roka, F., Petit, L., de Coppet, P., Tissot, M., Barrett, P., Morgan, P.J., Nanoff, C., Strosberg, A.D. & Jockers, R. "Dual signalling
of human Mel1a Melatonin receptors via Gi2, Gi3 and Gq/11 proteins" Mol. Endocrinol. 13, 2025-2038 (1999).
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327. Gros, J., Gerhardt, C. & Strosberg, A.D. "Expression of human beta3-adrenergic receptor induces adipocyte-like features in CHO/K1
fibroblasts" J. Cell Sci. 112, 3791-3797 (1999).
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326. Jockers, R., Angers, S., Da Silva, A., Benaroch, P., Strosberg, A.D., Bouvier, M. & Marullo, S. "Beta2-adrenergic receptors down-regulation:
evidence for a pathway that does not require endocytosis" J. Biol. Chem. 274, 28900-28908 (1999).
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325. Petit, L., Lacroix, I., de Coppet, P., Strosberg, A.D. & Jockers, R. "Differential signaling of human Mel1a and Mel1b melatonin receptors
through the cyclic Guanosine 3'-5' monophosphate pathway" Biochem. Pharmacol. 58, 633-639 (1999).
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324. Laisney, I.L. & Strosberg, A.D. "Dual specificity of a human neutralizing monoclonal antibody, specific for the V3 loop of gp120 (HIV-1)" Immunology Lett. 67, 185-192 (1999).
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323. Roulot, D., Sevcsik, A.M., Coste, T., Strosberg, A.D. & Marullo, S. "Role of transforming growth factor b type II receptor in hepatic fibrosis: studies of humanchronic hepatitis C and experimental fibrosis in rat" Hepatology 29, 1730-1738 (1999).
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322. Federici, C., Eshdat, Y., Richard, I., Bertin, B., Guillaume, J.L., Hattab, M., Beckmann, J., Strosberg, A.D. & Camoin, L. "Purification and
identification of two putative autolytic sites in human calpain 3 (p94) expressed in heterologous systems" Arch. Biochem. & Biophysics
363, 237-245 (1999).
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321. Strobel, A., Siquier, K., Zilberfarb, V., Strosberg, A.D. & Issad, T. "Effect of thiazolidinediones on UCP2 expression in human PAZ-6 adipocytes" Diabetologia 42, 527-533 (1999).
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320. Etienne, S., Bourdoulous, S., Strosberg, A.D. & Couraud, P.O. "MHC class II engagement in brain endothelial cells induces protein kinases
IL-6secretion and phosphorylation of cAMP response element-binding protein" J. Immunol. 163, 3636-3641 (1999).
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319. Faltin, Z., Camoin, L., Ben-Hayyim, G., Perl, A., Beeor-Tzahar, T., Strosberg, A.D., Holland, D. Eshdat, Y. "Cysteine is the presumed
catalytic residue of Citrus sinensis phospholipid hydroperoxide glutathione peroxidase over-expressed under salt stress."
Physiol. Plant 104, 741-746 (1999).
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318. Luyckx, F.H., Scheen, A.J., Strosberg, A.D., Gielen, J.E. & Lefèbvre, P.J. "Influence of the A ? G (-3826) uncoupling protein-1 gene (UCP1) variant on the dynamics of body weight before and after gastroplasty in morbidly obese subjects" Int. J. Obesity Relat. Metab. Disord. 22, 1244-1245 (1999).
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317. Strosberg, A.D. & Issad, T. "The role of mutations in leptin and leptin receptors' genes in human obesity and reproductive function" Tr. in Pharmacol. Sci. 20, 227-230 (1999).
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316. Gerhardt, C.C., Gros, J., Strosberg, A.D. & Issad, T. "Stimulation of ERK1/2 pathway by the human beta3-adrenergic receptor: new
pharmacological profile and mechanism of activation" Mol. Pharmacol. 55, 255-262 (1999).
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315. Roka, F., Brydon, L., Waldhoer, M., Strosberg, A.D., Freissmuth, M., Jockers, R. & Nanoff, C. "Tight association of the human Mel1a-melatonin receptor and Gi: precoupling and constitutive activity" Mol. Pharmacol. 56, 1014-1024 (1999).
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314. Strobel, A., Issad, T., Camoin, L., Ozata, M. & Strosberg, A.D. "A leptin missense mutation associated with hypogonadism and morbid obesity" Nature Genetics 18, 213-215 (1998).
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313. Issad, T., Strobel, A., Camoin, L., Ozata, M. & Strosberg, A.D. "La leptine : un signal pour le déclenchement de la puberté dans l'espèce humaine" Med/Sci 14, 349-351 (1998).
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312. Anthony, A., Schepelmann, S., Guillaume, J.L., Strosberg, A.D., Dhillon, A.P., Pounder, R.E. & Wakefield, A.J. "Localization of the beta3-adrenoceptor in the human gastrointestinal tract: an immuno-histochemical study" Alimentary & Pharmacol. Ther. 12, 519-525 (1998).
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311. Jockers, R., Issad, T., Zilberfarb, V., de Coppet, P., Marullo, S. & Strosberg, A.D. "Desensitization of the beta-adrenergic response in human brown adipocytes" Endocrinology 136, 2676-2684 (1998).
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310. Strosberg, A.D., Gerhardt, C., Gros, J., Jockers, R. & Piétri-Rouxel, F. "On the putative existence of a fourth beta-adrenoceptor: proof is still missing" Tr. in Pharmacol. Sci. 19, 165-166 (1998).
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309. Piétri-Rouxel, F. & Strosberg, A.D. "Les récepteurs beta-adrénergiques et le tissu adipeux" Reprod. Hum. & Hormones 11, 493-497 (1998).319.
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308. Jockers, R., Petit, L., Brydon, L., de Coppet, P. & Strosberg, A.D. "Structure et fonction des récepteurs de la mélatonine."
C.R. Soc. Biol. 192, 659-667 (1998).
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307. Strobel, A., Combettes-Souverain, M., Doaré, L., Strosberg, A.D. & Issad, T. "Rat Uncoupling Protein 2 (UCP2): Expression in obese
ventromedial hypothalamus (VMH)-lesioned animals" Int. J. Obes. 22, 1121-1126 (1998).
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306. Issad, T., Strobel, A., Camoin, L., Ozata, M. & Strosberg, A.D. "Leptine et puberté dans l'espèce humaine : l'hypothèse de la masse
adipeuse critique réactualisée " Diabetes & Metabolism 24, 376-378 (1998).
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305. Etienne, S., Adamson, P., Greenwood, J., Strosberg, A.D. Cazaubon, S. & Couraud, P.O. "ICAM-1 signalling pathways associated with
Rho activation in microvascular brain endothelial cells" J. Immunol. 161, 5755-5761 (1998).
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304. Strosberg, A.D. "Les signaux cellulaires passés au crible" Biofutur 184, 45-47 (1998).
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303. Ito, M., Grujic, D., Abel, E.D., Vidal-Puig, A., Susulic, V.S., Lawitts, J., Strosberg, A.D. & Lowell, B.B. "Mice expressing human but not
murine beta3-adrenergic receptors under the control of human gene regulatory elements" Diabetes 47, 1464-1471 (1998).
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302. Petit, L., Guardiola, B., Delagrange, P., Jockers, R. & Strosberg, A.D. "Signalisation des récepteurs de la mélatonine" Thérapie 53, 421-428 (1998).
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301. Lenzen, G., Pietri-Rouxel, F., Drumare, M.F., Amiard, A., Guillot, S., Archimbault, P. & Strosberg, A.D. "Genomic cloning and species-specific
properties of the recombinant canine beta3-adrenoceptor" Eur. J. Pharmacol. 363, 217-227 (1998).
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300. Romero, I.A., Texeira, A., Strosberg, A.D., Cazaubon, S. & Couraud, P.O. "The HIV-1 nef protein inhibits extracellular signal regulated
kinase-dependent DNA synthesis in a human astrocytic cell line" J. Neurochem. 70, 778-785 (1998). ...................................................................................................................................................................................................................................
299. Strosberg, A.D. "Structure and function of the beta 3 adrenoreceptor" Adv. Pharmacol. 42, 511-513 (1998)

298. Strosberg, A.D. "Association of beta3-adrenoreceptor polymorphism with obesity and diabetes: current status" Tr. in Pharmacol. Sci. 18, 449-454 (1997).
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297. Sibille, P. & Strosberg, A.D. "The epitope of a monoclonal anti-FIV antibody defined by screening a phage peptide library" Immunol. Lett. 59, 33-137 (1997).
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296. Clément, K., Manning, B., Basdevant, A., Strosberg, A.D., Guy-Grand, B. & Froguel, P. "Gender effect of the Trp64Arg mutation in the
beta3-adrenergic receptor gene on weight gain in morbid obesity" Diabetes & Metabolism 23, 424-427 (1997).
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295. Strosberg, A.D. "Towards the development and use of human-selective agonists for the pharmacologic treatment of obesity and diabetes." J. Endocrinol. 155, 221-222 (1997).
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294. Loisel, T.P., Ansanay, H., St-Onge, S., Gay, B., Boulanger, P., Strosberg, A.D., Marullo, S. & Bouvier, M. "Recovery of homogeneous and
functional beta2-adrenergic receptors from extracellular baculovirus particles" Nature Biotech. 15, 1300-1304 (1997).
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293. Zhang, J.M., Dix, J., Langtimm-Sedlack, C.J., Trusk, T., Schroeder, B., Hoffmann, R., Strosberg, A.D., Winslow, J.W. & Sieber-Blum, M.
"Neurotrophin-3-and norepinephrine-mediated adrenergic differentiation and the inhibitory action of desipramine and cocaine."
J. Neurobiol. 32, 262-280 (1997).
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292. Piétri-Rouxel, F., Manning, B., Gros, J. & Strosberg, A.D. "The biochemical effect of the naturally occuring Trp64Arg mutation on human
beta3-adrenoceptor activity" Eur. J. Biochem. 247, 1174-1179 (1997).
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291. Bertin, B., Jockers, R., Strosberg, A.D. & Marullo, S. "Activation of a beta2-adrenergic receptor/Gsa fusion protein elicits a
desensitization-resistant cAMP signal capable of inhibiting proliferation of two cancer cell lines" Receptors & Channels 5, 41-51 (1997).
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290. Cazaubon, S., Chaverot, N., Romero, I.A., Girault, J.A., Adamson, P., Strosberg, A.D. & Couraud, P.O. "Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and independent pathways" J. Neurosci. 17, 6203-6212 (1997).
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289. Barrett, P., Conway, S., Jockers, R., Strosberg, A.D., Guardiola, B., Delagrange, P. & Morgan P.J. "Cloning and expression of a polymorphic
variant of the ovine Mel 1a melatonin receptor" Biochem. Biophys. Acta 1356, 299-307 (1997).
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288. Sugasawa, T., Matsuzaki- Fujita, M., Guillaume, J.L., Camoin, L., Morooka, S. & Strosberg, A.D. "Characterization of a novel 34kDa SM-11044 binding protein, which may mediate relaxation of depolarized rat colon tonus" J. Biol. Chem. 272 , 21244-21252 (1997).
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287. Bailleul, B., Akerblom, I. & Strosberg, A.D. "The leptin receptor promoter controls the expression of a second distinct leptin receptor
gene-related protein."Nucl. Acid Res. 25, 2752-2758 (1997).
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286. Jockers, R., Petit, L., Lacroix, I., de Coppet, P., Barrett, P., Morgan, P.J., Guardiola, B., Delagrange, P., Marullo, S. & Strosberg, A.D.
"Novel isoforms of Mel1c melatonin receptors modulating intracellular cGMP levels" Mol. Endocrinol. 11, 1070-1081 (1997).
...................................................................................................................................................................................................................................
285. Bedecs, K., Elbaz, N., Sutren, M., Masson, M., Susini, C., Strosberg, A.D. & Nahmias, C. "Angiotensin AT2 receptors inhibit epidermal growth factor-induced mitogen-activated protein kinase cascade and stimulate the catalytic activity of protein tyrosine phosphatase SHP-1" Biochem. J. 325, 449-454 (1997).
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284. Bertin, B., Strosberg, A.D. & Marullo, S. "The human beta2-adrenergic receptor/Gsa fusion protein expressed in two ras-dependent
murine carcinoma cell lines prevents tumor growth in syngeneic mice" Int. J. Cancer 71, 1029-1034 (1997).
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283. Gotoda, T., Manning, B., Goldstone, A.P., Imrie, H., Evans, A.L., Strosberg, A.D., McKeigue, P.M., Scott, J. & Aitman T.J. "Leptin receptor gene variation and obesity: lack of association in a white British male population" Hum. Mol. Genetics 6, 869-876 (1997).
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282. Conway, S., Drew, J.E., Canning, S.J., Barrett, P., Jockers, R., Strosberg, A.D., Guardiola-Lemaitre, B., Delagrange, P. & Morgan P.J.
"Identification of Mel 1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled receptors
which do ot mediate the nhibition of stimulated cyclicAMP levels" FEBS Lett. 407, 121-126 (1997).
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281. Sibille, P., Ternynck, T., Nato, F., Buttin, G., Strosberg, A.D. & Avrameas, A. "Mimotopes recognized by polyreactive anti-DNA antibodies"
Eur. J. Immunol. 27, 1221-1228 (1997).
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280. Zilberfarb, V., Piétri-Rouxel, F., Jockers, R., Krief, S., Delouis, C., Issad, T. & Strosberg, A.D. "Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis" J. Cell Sci. 110, 801-807 (1997). ...................................................................................................................................................................................................................................
279. Strosberg, A.D. "Structure and function of the beta 3-adrenergic receptor"Ann. Rev. Pharmacol Toxicol. 37, 421-450 (1997).
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278. Piétri-Rouxel, F. & Strosberg, A.D."Le récepteur beta3-adrénergique humain: le poids des faits" Médecine/Sci. 13, 283-284 (1997).
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277. Quinonero, J., Tchélingérian J.L., Vignais, L., Foignant-Chaverot, N., Colin, C., Horellou, P., Liblau, R., Barbin, G., Strosberg, A.D., Jacque, C. Couraud, P.O. "Gene transfer to the central nervous system by transplantation of cerebral endothelial cells". Gene Therapy 4, 111-119 (1997).
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276. Strosberg, A.D. & Pietri-Rouxel, F. "The beta3-adrenoceptor constitutes indeed a versatile receptor" Tr. in Pharmacol. Sci. 18, 52 (1997).

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